منابع مشابه
Adjuvant Therapy: Melanoma
With an incidence that is increasing at 2-5% per year, cutaneous melanoma is an international scourge that disproportionately targets young individuals. Despite much research, the treatment of advanced disease is still quite challenging. Immunotherapy with high-dose interferon-α2b or interleukin-2 benefits a select group of patients in the adjuvant and metastatic settings, respectively, with si...
متن کاملAdjuvant therapy of melanoma.
In 2001, the American Joint Committee on Cancer Melanoma Staging Committee proposed and created a new staging system for melanoma. This new system will become official in 2002, with the publication of the sixth edition of the AJCC Cancer Staging Manual. The new system identifies significant prognostic variables in patients with melanoma and validates them in an analysis of 17,600 patients, maki...
متن کاملAdjuvant therapy for high-risk melanoma
Adjuvant vaccine trials in melanoma thus far have failed, results ranging from ineffective (three randomized controlled trial (RCTs) [1]) to harmful (three RCTs [2–4]). Two large trials with Canvaxin ended early because of a detrimental outcome for the vaccine arm. Two large trials with the GMK vaccine (ganglioside GM2/KLH/QS-21) were also stopped early because of inferior outcome in the vaccin...
متن کاملAdjuvant therapy for High-risk Melanoma
Introduction High-risk resected melanoma signifies a group of patients that carries a risk of melanoma recurrence and death after initial surgical resection that may be defined as 35% to 40% or higher and includes patients with American Joint committee on cancer (AJcc) stages IIb, IIc, III, and IV. the development of local or regional recurrence after initial surgical management portends an eve...
متن کاملChoices in adjuvant therapy of melanoma.
BACKGROUND High-dose interferon (IFN) is the approved agent for adjuvant treatment of melanoma in the United States. This approval is for high-risk, predominantly stage III patients with cutaneous primaries. There are still decisions to be made in the care of these patients. Also, there are questions about whether the IFN data can be extrapolated to patients with other stages of melanoma and wh...
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ژورنال
عنوان ژورنال: Current Oncology Reports
سال: 2017
ISSN: 1523-3790,1534-6269
DOI: 10.1007/s11912-017-0594-5